Just got back from our first multi day (2 week) “RV-less” trip since 2005, running just over 2800 miles. It was nice to be able to stop wherever we wanted w/o having to find a place to park. The Tundra provided a smooth ride and did 16+ mpg running 75+-. We had to stop more but it was a good chance to stretch. Driving comfort was good as it was much easier to maneuver. Downsides included having to unload and load luggage each stopover. Overall cost was slightly less compared to the RV as motel and food costs ate up any fuel savings. IMHO the RV was a much more convenient way to travel but not having to deal with all the little (and large) issues that can occur on and after a trip seem to balance things out.
Steve