Doug,
Air is 78% Nitrogen, 18% oxygen, and trace gasses plus water vapor. If you use Nitrogen you get about 93% into a tire because they do not allow evacuation with vacuum to deform a tire before filling it because it damages it. So what you are getting in reality is roughly the same mix of gasses plus about 15% more nitrogen. When you look at gas expansion with temperature there really is no difference regarding the gasses, but there is a real difference in expansion of the water molecules. As the temperature rises while driving, the water molecules will vaporize into a gas, and that transition from a liquid to a gas is responsible for most all the rise in tire pressure.
I think the thing to focus on is the moisture and not so much the gas mix. Keep as much moisture out of your tires as possible.
I had several Michelin tire fails in my last coach and working with their reliability engineers we believed that moisture in the tire caused failure in the following way. I live along the gulf coast, very high humidity and moisture saturated air. My coach sits during the winter when the moisture condenses. I added air without a water separator using a small compressor that I carry with me. When my tire failed (sidewall zipper fail) I noticed that the steel cables had some rust on them. With steel cable roughness and the elongation and contraction motion of the steel cables with each revolution, Michelin believed they actually sawed themselves. So when I sat in the winter the moisture was being driven slowly through the sidewall and condensed on the steel cords and rusted them. Truckers do not have the issue because the tires do not sit, this fail is unique to RVs. Michelin increased the thickness of the barrier coat which is on the inner surface of the tire and is the layer responsible for maintaining pressure and is the barrier to gas and moisture migration through the sidewall.
I have added a water separator to my travel compressor and fill when the humidity is low. I use my home compressor when ever possible given it has a better water separator system on it.
This is my two cents on focusing on what I think is important which is the moisture. In a round about way using nitrogen gets you to a low moisture state in a tire given it is a demoisturized gas, but it is an expensive way to get there. I can see no other benefit to having nitrogen in a tire for our application.
Later Ed