We live in Southern Oregon and drive 140 to Winnemucca, NV regularly. Other than long stretches of "nothing", it's no big deal. The grades are actually mild compared to many other highways. There is one grade that lasts a bit, but there is no traffic on this road, so if you are climbing slow, there's usually no one behind you. I wouldn't worry about no cell coverage in areas, if you need help, it's part of the country where people will stop lend a hand. It's just a long distance to anything so people have a different mindset. One time we had to sit on the highway for 20 minutes while a large herd of cattle could be given driven down the road. That's what make 140 unique.