Neil,
There is no easy answer to your question. The service intervals that the air dryer manufacturer gives for the unit are based on it's application in the heavy duty trucks that it was designed for. In a motorhome the air dryer will see less use in the life of the coach that a 18 wheeler will see in a year. Therefore, my viewpoint is that as long as it is doing it's job an you never get water when bleeding the tanks, it is OK and does not need service. However, if you are getting water when you bleed the tanks, it is time for service.
Gerald