I've commonly set at least one thermostat at 40-45, with the HydroHot electric on. Draining lines at the manifold can't hurt, and any fridge icemaker drain valve near the water pump. At 25 I'd consider kicking on the diesel side of the HydroHot, rather than just the electric side, or if it was 30 for a lot more than just a few overnight hours. I'd check it immediately prior to the outside temp hitting freezing to make sure the furnace was fully functional. Usually, as Bill alludes to, the weather has to not just reach sub-freezing, but stay there for quite awhile before things inside are really in jeopardy.
Joel