We RVed out of AZ but the majority of our relatives were in the SE. Living in the Phoenix area we had easy access to I10/I20 and I40. In the summer we would run I40 and winter I10 or I10-20 depending our ultimate destination. Overall we preferred I40 above the other 2. There is better scenery (IMHO) along I40 and also more points of interest (again IMHO). Bearazona in Williams, AZ is a must see. White Buffao, Bears, Wolves, Sheep, etc area all in there natural settings as you drive through the park. In Flagstaff, Black Barts RV park and steakhouse are great. Servers are college students who also serenade you. Galllup NM has some very good Indian jewelry spots that aren't ripoffs. Albuquerque has any number of attraction. NM Mexican food is IMHO the best in the country. If you are adventurous head south on I25 in Albuquerque and pick up US 60 west bound in Socorro, NM. You'll travel through a number or quaint small towns with good homestyle restaurants in all. Do not speed in Magalena and if you like pie, Pie Town is a must stop. The Very Large Array of radio telescopes is located on the Plains of St Augustine. In Showlow AZ you'll have to decide whether to head to Phoenix via Payson or stay on US 60. The former is dual lane most of the way to Phx. US 60 routes you through Sal River Canyon. It's beautiful with many overlooks for photos, etc. However, avoid it if your exhaust brake, coach brakes and cooling system are not in good shape as you will drop 2000 ft and then climb back out in about a 2-3 mile horizontal span.
The only downside of I40 is OK & TX due to possible summer storms.
Steve