Jeremy,
All eight wheels on your coach are the same 8.25 inches in width, and will run 295/80/22.5 tires well. The only difference in your wheels is that the rear inside duals are 8.25 inch steel wheels instead of aluminum.
The front axle on your coach will be overloaded with 11R22.5 tires just as all tires on my 2000 Marquis were because it is a 40 foot with no tag axle. When I weighed my coach with the 11R22.5 tires that it came with, all tires were overloaded at 120 PSI except the left front. Your coach may be able to run 11R22.5 tires on the drivers and tag since you have the extra pair of tires to support the load. You may even be able to buy the 11R22.5 tires cheaper since they are a very common size for trucks that are limited to 20,000 pounds per axle, as opposed to the nearly 24,000 pounds that is on my drive axle.
Gerald