Thanks Guys.
Leah, the spotty-looking stuff is just water droplets that have condensed out and perhaps look dark against the sky; there is no mold.
The coach has been parked on our pad for over 2 years, and this problem didn't appear until last summer and fall. I checked the roof seals and can find no problems, nor does the outer dark panel appear deteriorated or cracked in any way. I'm pretty sure the moisture didn't get between the panels via liquid water, but rather by humid air. Like the telltale fog on our entry door window, I began noticing a slight fog on the skylight last year, but did not assume at first that it was between the panels. Then in time I noticed the fogging had increased and was coalescing into droplets in places, and closer examination proved it was between panels. It got worse by late fall, and during the cold winter, it all condensed into a pool at the low end. With Spring sunshine, the pool is beginning to re-evaporate as in the photo.
Having dealt with dry rot in the roof of a previous coach, I am paranoid about moisture breaking the roof barrier anywhere, thus my concern about the skylight's ability to hold that water inside itself. I'll probably go over the outside with a fine-toothed comb to be sure, and remove the inside skylight ceiling moulding to check for a hidden breach or crack there that could be siliconed over. But any humid air left inside will fog in the summer, and getting existing moisture totally out before resealing ... well, I'll need genius or good luck for that, and I'm not even 50/50 on that!
Last summer in the Northwest was one of the wettest on record, but I still didn't think I needed to run an air dryer and dessicants inside Monty Rae like I do in the winter. I suspect unusually humid air infiltrated the skylight from the inside then, and slowly built up over time. Barring a found breach, I may try a drain hole or two, but if fogging continues, I'll replace it; sounds like the work removing/replacing it and two kinds of sealants is more costly than a new unit itself.
-Joel