Marty,
You can run 315/80/22.5 tires on 8.25 wheels, but as Tim said, your load capacity will be reduced with the narrower wheels. On 9 inch wheels 315s have a max load of 9,090 pounds at 130 PSI, but on 8.25 inch wheels the max load is 8,000 pounds at 120 PSI. Below is a line from the Michelin RV tire guide.
) For use with 8.25 x 22.5 wheels, see Page 20. When mounting the 315/80R22.5 LRL on an 8.25" wheel, do not load or inflate to the maximum load or inflation pressure indicated on the sidewall. The maximum load per tire for the 315/80R22.5 LRL, single mount on an 8.25" wheel, is 8000 lbs at 120 PSI (3630 kg at 830 kPa).
Gerald